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Semaglutide releases GLP-1, a hormone that reduces blood sugar

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[15] [16] Constipation paradoxically affects 10-20% of patients, demonstrating that GLP-1 medications can slow bowel transit to varying degrees in different individuals

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Safety and tolerability outcomes comprised discontinuation of treatment due to adverse events, incidence of serious adverse events, all-cause mortality, hypoglycaemia (plasma glucose 3.9 mmol/l), severe hypoglycaemia (a hypoglycaemic event requiring assistance), nausea, vomiting and diarrhoea