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Factors such as cost savings, convenience, absorption issues, potential digestion, and comfort with self-administering injections can affect patients preferences

According to Johns Hopkins Medicine, a lack of vitamin B12 may result in vitamin B12 deficiency anemia

Vitamin B12 supplied as cyanocobalamin or hydroxocobalamin acts through its coenzymes in many metabolic processes including the synthesis of myelin, essential lipoprotein for the integrity of the nervous and peripheral system (antineuritic action)

Regular exercise can also help to keep stress at bay by increasing endorphin (feel good hormone) production, which helps to improve mood and positively impact the cardiovascular system

This foundational work established the mechanism that underpins subsequent clinical research