The Canadian context adds unique considerations
coli express a type III RNR that can use either reducing power supplied by Trx or Grx, or can directly use the oxidation of formate, to generate a thiyl radical in the RNR active site and thereby drive the reduction of ribonucleotides [87, 88]
Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence
The low dose is doing its job, priming your system for what comes next
Some patients notice improvement within several weeks, while others experience more gradual benefits depending on the condition being treated
How should I scale it down
