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[42] pooled 31 long-duration RCTs (84,713 participants) of GLP-1 RAs in diabetes and obesity, populations again largely free of significant psychiatric comorbidity, and found no increase in depression, anxiety, or suicidality, providing robust evidence for psychiatric safety in large, controlled settings

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continuously fed a diet containing NAC + Gly to aged male mice for eight weeks, which corrected GSH levels and promoted the expression of GSH synthesis enzymes (GCLC, GCLM and GS) in the heart, liver and kidney, prolonging the lifespan of aged mice [50]