Escalation: Increase to 4 mg weekly (Weeks 58), then 8 mg weekly (Weeks 912) [1]
For weight loss, studies suggest semaglutide is safe and effective for at least four years, but most weight loss happens in the first year
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Eligibility criteria Inclusion criteria for original articles encompassed: (1) interventional studies (clinical trials, randomized controlled trials) evaluating gastrointestinal adverse events associated with GLP-1 RAs in non-diabetic patients with overweight or obesity
A 2023 analysis found that participants who discontinued semaglutide after 68 weeks of treatment regained approximately two-thirds of their lost weight within one year
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