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Theranostics (2020) 10(12):541234

Tirzepatide suppresses this compensatory ghrelin increase through central nervous system effects, breaking the typical hunger rebound cycle

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In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)