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Mechanistically, LONP1 promotes proliferation and migration of pulmonary artery smooth muscle cells by directly binding to and degrading mitochondrial pyruvate carrier 1 (MPC1), leading to pulmonary vascular remodeling and ultimately promoting the development of PH [76]

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For crystallographic fragment screening, we soaked 983 fragments from three fragment libraries (the DSiP fragment library 32 , the EUbOPEN DSiP extension library, and the FragLite library 33 ) as singletons into TRF1 TRFH crystal drops

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PDSS2 Inhibits The Ferroptosis Of Vascular Endothelial Cells In Atherosclerosis By Activating Nrf2