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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Drucker D.J., Buse J.B., Taylor K., et al

Science 353 , 11611165 (2016)

Previous studies have found benefits of intermittent fasting without calorie restriction in mice, finding that intermittent fasting improved glucose metabolism, regulates circadian rhythms, and promotes neuronal resilience as well as recovery from neural injury 48,49,50,51

IGF-1's suppression of GH secretion through negative feedback indirectly improves metabolic function by reducing GH-mediated lipolysis and its associated insulin-antagonistic effects