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Tirzepatide, a dual GLP-1/GIP receptor agonist, has a shorter half-life of approximately 5 days but achieves sustained receptor activation through extended tissue binding

If you started a new medication around the time you noticed the change, that connection is worth mentioning to your prescribing clinician

& Kollman, J

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168,169 Consumption of pomegranate polyphenols significantly lowered total and LDL cholesterol concentrations while maintaining HDL levels in subjects with elevated cholesterol profiles

Because responses vary dramatically on factors a casual post never captures