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Nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons

This response involves multiple cell types

doi: 10.1016/j.ejphar.2020.172909 [DOI] [PubMed] [Google Scholar] 9

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Deeper metabolic changes fat burning, endurance typically become measurable at eight to twelve weeks of consistent use