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Alpha-lipoic acid protects mitochondria by removing free radicals and improves the recycling of other antioxidants

The canonical NF-kB pathway can be activated by OS and/or proinflammatory cytokines [188]

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This timing leverages physiologic factors including reduced somatostatin inhibition during sleep, increased GHRH receptor sensitivity during evening hours, and optimal metabolic conditions supporting growth hormone synthesis and secretion, while morning or midday administration stimulates smaller daytime pulses with less consistent metabolic benefits

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