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Trevisan M, Fu EL, Szummer K, Norhammar A, Lundman P, Wanner C, Sjlander A, Jernberg T, Carrero JJ: Glucagon-like peptide-1 receptor agonists and the risk of cardiovascular events in diabetes patients surviving an acute myocardial infarction

We observed a change in the fluorescence lifetime from 1.3 ns in an NADP + -saturated state to 2.3 ns in an NADPH-saturated state, which is exceptionally large for a fluorescent protein-based biosensor

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Mechanistically, YTHDF2 recognized m6A-modified ZHX2 mRNA and promoted its degradation

The peptide also does not stimulate IGF-1 production, avoiding the growth-promoting and potentially mitogenic effects associated with IGF-1 elevation

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