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Accurate measurement requires imaging such as CT, MRI, DEXA, or validated ultrasound, or clinical proxies such as changes in waist circumference, fasting insulin, HOMA-IR, or liver enzymes

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Gut 63:727735 Burton JH, Johnson M, Johnson J, Hsia DS, Greenway FL, Heiman ML (2015) Addition of a gastrointestinal microbiome modulator to metformin improves metformin tolerance and fasting glucose levels