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Limitations: Side Effects and Chronic Use Requirement Semaglutide's most common adverse effects are gastrointestinal

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Structural Modification 3: C18 Fatty Diacid Lipidation The Mechanism of Half-Life Extension The most consequential structural modification in cagrilintide -- and the one that defines it as a "long-acting" analog -- is the attachment of a C18 fatty diacid chain via a structured hydrophilic linker