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NICE obesity guidance (CG189) recommends multicomponent interventions addressing diet, physical activity, and behaviour change as first-line management

[DOI] [PubMed] [Google Scholar] 57.Ehrbar M., Zeisberger S.M., Raeber G.P., Hubbell J.A., Schnell C., Zisch A.H

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Realistic expectations include progressive weight loss over a 12-20 week initial period, with the most significant changes becoming apparent after dose escalation is complete