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Finally, we confirmed that the PPARa-FSP1 pathway modulated neuronal responses to lipid peroxidation-induced ferroptosis following TSCI, promoting functional recovery

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The fundamental distinction lies in the mechanism of action: GLP-1 agonists are receptor-specific molecules that directly stimulate GLP-1 receptors, while berberine exerts its metabolic effects primarily through AMPK activation and other pathways that do not involve direct GLP-1 receptor engagement