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Pickart's foundational work and subsequent studies on copper peptides and wound closure point to upregulation of matrix metalloproteinases, the enzymes responsible for remodeling collagen into organized structure during repair, rather than the disorganized collagen deposition that produces visible scarring

M.CrowleyJ

Free Radical Biology & Medicine, 26(3-4), 463471

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However, 2D cultures oversimplify the cellular architecture and fail to capture the complex brain microenvironment (Acharya et al., 2024)