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For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said

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For comparison, liraglutide 3.0 mg (the active comparator) produced 9.0% reduction

This structural change dramatically reduces IGF-1s binding affinity for IGFBPs (insulin-like growth factor-binding proteins), thereby extending its active half-life from approximately 12 minutes to 2030 hours