Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models
As part of the deal, Novo said it will dismiss its lawsuit against the company
Patients will receive detailed counseling about risks, benefits, and unknowns when it becomes available
Retatrutide is an investigational triple agonist that simultaneously targets three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]
The drug is in later-stage clinical trials, with phase 3 trials underway to determine broader efficacy and safety