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Some individuals have genetic variants in the GLP1R gene (such as rs6923761) that affect receptor sensitivity, meaning they experience more pronounced nausea or fullness from sugar, while others have variants in FTO or MC4R genes that influence baseline hunger and satiety set points

This can reduce unwanted side effects that have been common with other similar growth hormone stimulators

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They act on receptors primarily the GHRH receptor or the ghrelin receptor (GHS-R1a) to amplify the pituitary's natural signalling

However, it is normal to feel hungry while taking the medication as it reduces appetite but does not get rid of it completely

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