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FIGURE 5 In vitro inhibition of oxidative stress in human alveolar epithelial cell by GHK-Cu via the upregulation of Nrf2 level After applying 5% CSE into A549 cells for 24 h, we found that the MDA level was increased, and the levels of T-AOC and GSH were decreased compared with those in A549 cells without CSE exposure, indicating that CSE stimulates an increase in oxidative stress in human alveolar epithelial cells

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A reduction in microbiome diversity has been identified (191), but it is likely that the microbiome composition will differ between ME/CFS patients as each patient has a unique infectious history (193)

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