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Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo J Neural Transm 1991

Shechter, A., Varin, F

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Their belief is that insulin, by way of inhibiting release of stored fat, causes the other tissues to sense an energy deficit (since the energy is trapped in adipose) and thus we overeat in order to provide fuel to the tissues that feel they are starving. As Guyenet points out on his website, according to this model, high calorie intake and low calorie expenditure are the RESULT of expanding fat tissue, not its cause. This is in stark contrast to the energy balance model accepted by most nutrition scientists where fat accumulation is a result of an imbalance between energy intake and expenditure

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