This disruption may lead to reduced secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, ultimately resulting in anovulation (absence of ovulation) and menstrual irregularities, including missed periods
Additionally, skin ulceration, severe infection, and gangrene in the feet can lead to amputation and life threating complications
[1] [3] This medication works by mimicking the action of naturally occurring GLP-1, a hormone that regulates blood glucose levels by stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptying
For some, it can take years before a deficiency occurs, for others, symptoms develop much sooner
This slow approach is designed to reduce side effects
However, robust evidence on their effects on body weight, obesity-related metabolic changes, and safety in children and adolescents with obesity remains limited, making them a subpopulation with scant treatment options
