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CCAS can also be seen in complex cerebrocerebellar pathological conditions, such as cerebellar and brainstem hemorrhage, complex cerebrocerebellar degeneration with gene variants (senataxin, gene, and X-linked recessive ATP2B3 gene), pontine cavernous malformation, ataxia with oculomotor apraxia type 2 (AOA2), Friedreichs ataxia, SCA1, SCA2, SCA3, SCA7, SCA17, and multiple system atrophy of the cerebellar type (MSA-C) [9]

Catalases are enzymes that catalyze the conversion of hydrogen peroxide to water and oxygen, using either an iron or manganese cofactor