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The areas thus obtained for standard TMA were correlated with the area of the internal standard, and the resulting ratio (TMA/D9-TMA or TMAO/D9-TMAO) was correlated with the standard concentration to verify the range of linearity of the response, which was in the range from 25 nM to 100 M

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732,750 The concentration of 12/15-ALOX in the brain increases significantly after 90 minutes of MCAO/R, and 12/15-LOX knockout mice exhibit reduced cerebral edema and infarct volume compared to wild-type mice following MCAO/R

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