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While all groups experienced some decline in FEV1 over 52 weeks, the 25-mg dose limited this decline to just 24 mL compared to 62 mL with placebo, a difference that reached statistical significance ( 6.1.3.3 Safety profile and tolerability Throughout the 52-week treatment period, brensocatib demonstrated a reassuring safety profile

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Patients with ASD will show diverse efficacy in response to the same treatment and intervention ( in vitro studies, their low bioavailability limits their activities in the target tissues in vivo studies (60)

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BPC-157 BPC-157 was placed into Category 2 because the FDA identified safety concerns and a lack of adequate human clinical data