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The metabolic regulator ERRalpha, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer

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Li R, Lo EC, Liu BY, Wong MC, Chu CH

Gene and protein expression of key TCA enzymes is also reduced in these models, while milder impact models actually demonstrate a gradual increase in these enzymes as mice recover from impact [75]

A recent study revealed that triple-negative breast cancer (TNBC) exhibits the most severe circadian rhythm disruption among all subtypes, marked by loss of rhythmic gene expression, metabolic reprogramming, and an immunosuppressive microenvironment