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Furthermore, the HUVEC cells were incubated with different concentrations of uricase (0, 0.5, 1, 2.5, 5 U/mL), PDA@Pt (0, 25, 50, 75, 100 g/mL), and UA (1 mM) for 24 h

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Atwan A, Ingram JR, Abbott R, Kelson MJ, Pickles T, Bauer A, Piguet V

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Through a comprehensive analysis of histone modifications in lesional skin from both psoriasis patients and mice, the significantly increased level of histone acetylation at H4 lysine 16 (H4K16ac) in macrophages was found, which was positively correlated with the accumulation of self-RNA in the dermis and psoriasis pathology