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Start with a lower dose

Dihexa fits the criteria necessary for an effective anti-dementia drug: 1 ) it is orally active, as it survives passage through the gut and enters the brain

PMID: 25857584

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Mechanistically, an in vitro study found that exendin-4 inhibited the secretion of IL-1 and TNF- from mouse colonic smooth muscle cells (CSMCs) via the pathway mediated by cAMP and NF-B, thereby exerting anti-inflammatory effects [218]

injection of CCK, the number of Fos immunoreactive nuclei was counted in maximum projection confocal images through each region aided by Volocity software