Similarly, nicotinamide mononucleotide (NMN), a key intermediate in cellular energy metabolism, also decreases with age (Yoshino et al., 2018
The 2025 review describes this as Epithalon functioning as a precision gene-expression modulator rather than a blunt genetic tool, supporting reduced mutation load and enhanced DNA repair over time
What's your read on which consumer health company is best-positioned for the GLP-1 #adjacency play
In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]
Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2
Alkema W, Boekhorst J, Eijlander RT, Schnittger S, De Gruyter F, Lukovac S, Schilling K, Kortman GAM (2021) Charting host-microbe co-metabolism in skin aging and application to metagenomics data
