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PT-141 generally does not darken skin

For people with EDS who rely heavily on muscle strength to compensate for joint instability it's a more serious concern

17,20 Evaluation of contraindications, including a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, is also important when determining appropriateness of therapy

From other trials, there are health benefits in a reduction of weight-related comorbidities when individuals lose 5-10% of body weight, so it is very likely their health improved

Drschmann et al

As the kidneys receive ~ 25% of the cardiac output, a condition known as cardiorenal syndrome (CRS) can manifest when either the heart or the kidneys fail (Ronco et al