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8 CGM is now relevant even in T2D not using insulin

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Most patients tolerate this minor adjustment without significant issues, though staying hydrated and eating small, protein-rich meals can help manage any temporary nausea

In a third study estimating the prevalence of GLP-1 based therapy discontinuation among new users with T2DM or obesity, patients who had new GI adverse events at follow-up were reported to have a significantly higher odds of treatment discontinuation at 12 months compared with patients who did not have a new GI adverse event (odds ratio: 1.04

However, a smaller subset reports increased side effects on semaglutide despite tolerating tirzepatide well

SDF-1 may also play a critical role in the genesis of retinopathy, which starts with damage to small blood vessels in the eye but whose progression depends on a neovascular response that can be exacerbated by SDF-1 [18, 25]