Activation of GLP-1 receptors in cortical arterioles enhances cerebral blood flow and improves perfusion, which may promote neuroprotection against ischemic stroke [44]

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GLP-1 plays important physiological roles in regulating the glucose homeostasis stimulating the pancreatic secretion of insulin and inhibiting glucagon secretion [32]
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Reduction in liver fat and improvement in non-alcoholic fatty liver disease Decreased blood pressure (average 8-10 mmHg systolic reduction) Improved cholesterol profiles with increased HDL and reduced triglycerides Reduced inflammatory markers Significant improvements in mobility and physical functioning Enhanced quality of life scores across multiple domains These comprehensive health improvements make Mounjaro particularly valuable for Irish patients with obesity-related comorbidities