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Despite these differences, the consistent findings were that ABHD11 depletion or inhibition predominantly results in 2-OG and 2-HG accumulation and HIF-1 activation, which differed from conditions of glutarate excess

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Following the end of the sensation and motor studies, the rats were euthanized and both the left and right gastrocnemius muscles were dissected and weighed in order to compare the muscle mass of the operated limb (right) versus the non-operated limb (left) [2]

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Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues