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It helps keep brain cells safe from damage and works with neurotransmitters

After three decades and more than two hundred papers, there is still no published randomized controlled trial showing efficacy

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Additionally, activation of the HPA axis and prolonged elevation of cortisol exacerbate esophageal injury, while local and systemic immune inflammation further induces visceral hypersensitivity, creating a stress-induced neuroimmune loop

Cell Metab 2018;27:74056

Effect of procyanidine on VEGFR-2 expression and transduction pathway in rat endothelial progenitor cells under high glucose conditions