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Ghrelin is another possible player, since it has been proven to be expressed not only in the gut, but also in a distinct subpopulation of islet cells named -cells (231) and, being known to be a stress-induced (232) GLP-1 secretagogue (233, 234), it might play an important role in the intra-islet signaling

By facilitating this transport, these compounds help reduce the accumulation of partially oxidized substrates, minimising the excessive generation of ROS and contributing to the maintenance of mitochondrial redox homeostasis [28]

Staying hydrated is especially important since GLP-1 medications can reduce thirst for some people, and travel itself especially flying, hot weather, or long sightseeing days may already increase the risk of dehydration

[DOI] [PubMed] [Google Scholar] 38.Billington CJ, Briggs JE, Link JG, et al

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While technically possible for very short-term use, we dont recommend this practice