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J Phys: Conf Ser 2070(1):012180

The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2, thus preventing shutoff from host protein synthesis while enabling continuous production (11, 30, 31)

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The structure of PTEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation