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Early treatment phases typically start patients at lower unit amounts (2.4 units or 0.2 mg) and increase gradually every 4 weeks to allow the body to adjust and minimize nausea

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To examine molecular mechanisms of this phenomenon, exendin (939)specific inhibitor of GLP-1 receptor, Rp-cAMPthe cAMP inhibitor, PI3 K inhibitor LY294002 or p44/42 mitogen-activated protein kinase inhibitor UO126, were given concomitantly with GLP-1 + VP infusion

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