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Consistently with most previously published findings, Ji et al

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At the pathophysiological level, obesity is characterized not only by excessive adipose tissue accumulation but also by a state of chronic low-grade inflammation directly driven by weight excess and adipose tissue expansion (Figure 1

The GLP-1 RAs are eliminated by proteolytic degradation and their metabolism does not involve cytochrome P450 enzymes or transporter-mediated drug interactions.4 Therefore, the probability of interaction with immunosuppressive drugs is low