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Patients treated with Opdivo plus the two chemo agents and followed for approximately 33 months saw a 22% reduction in risk of death compared with chemotherapy alone

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(2018) Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors, Oncol

Meanwhile, Western blot manifested that apoptosis-related proteins (BAX, cleaved-caspase 9 and cleaved-caspase 3) were down-regulated, and anti-apoptosis protein Bcl-2 and cycle-associated proteins (Cyclin D1, CDK4 and CDK6) were up-regulated in T-BPH rats, all of which were reversed by TRO intervention (Fig

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Hu C, Chen Q, Wu T, et al