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Most primary care doctors aren't familiar with using naltrexone for alcohol, even though it's been FDA-approved since 1994

JCI Insight 2021;6

Another study reported BD patients (75 euthymic, 14 manic/hypomanic, 45 depressive) had higher levels of all cytokines, including slL-2R, C-reactive protein (CRP) and sTNFR1 than the healthy controls [73], with depressed BD patients having reduced sTNFRl and slL-2R compared to those in mania and euthymia [73]

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Though not a hit, the film was closely followed in the industry and helped Grillo get noticed