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Combination studies alongside GLP-1 agonists such as semaglutide

Although the significance of this finding requires further investigation, it suggests that GLP-1 RA therapy could help facilitate more adaptive behaviors, especially in individuals struggling with compulsive eating or substance use, by potentially enhancing their capacity for new learning and behavioral flexibility

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One of these mechanisms involves increased circulating FFAs, greater adiposity and ectopic fat deposits in skeletal muscle and the vasculature per se

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