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In diabetic state, hyperglycemia leads to overproduction of free radicals (i.e., mitochondrial , NO and peroxynitrite) mainly derived from glucose oxidation and lipid peroxidation, which cause oxidative damage to biomolecules

Obesity is a chronic condition, and patients may benefit from taking GLP-1s long term, especially if they also have conditions such as diabetes, cardiovascular disease, obstructive sleep apnea, or metabolic dysfunction-associated steatohepatitis (MASH)

The insulin glargine contained in Soliqua forms microprecipitates when injected under the skin (subcutaneously), which allows the insulin to be released slowly from the injection site

Rogachov et al., 2023)

If you notice redness, swelling, or blistering, stop the medication and get medical help immediately

Among ADMs, semaglutide continues to be the most prescribed medication (1.34% of all prescriptions) , although prescription rates decreased (-3.92%)