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An excess production of melanin can occur as a result of sun exposure or hormonal variability and may result in pigmentation, tanning and uneven tone

Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues

Moreover, GLP-1RA therapy leads to plaques characterized by reduced inflammation and increased stability due to suppression of matrix metalloproteinases and promotion of fibrous cap formation (44, 45)

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Clinical studies show reductions in inflammation markers like hs-CRP by up to 54% (NIH) and improvements in oxidative stress by 73% (NIH) with regular use

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