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Unlike other melanocortin peptides, KPV exhibits potent anti-inflammatory effects independent of melanocortin receptors

Otic agents and/or other pharmaceutical agents disclosed herein are optionally incorporated within controlled release particles, lipid complexes, liposomes, nanoparticles, microspheres, nanocapsules or other agents which enhance or facilitate the localized delivery of the otic agent

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Melanin production is accompanied by active production of ROS and melanin itself absorbs ultraviolet light, which causes oxidative stress