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Many of natural AMPs can be degraded by both host and bacterial proteases (Pero et al

doi: 10.1016/j.biopha.2023.116023 311 SnchezMCRibeiro-VidalHEsteban-FernndezABartolomBFigueroEMoreno-ArribasMVet al

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149 The following observations suggest that ammonia is the key mediator in hepatic encephalopathy: (a) ammonia levels are increased in 80% to 90% of patients with the condition, 150 (b) factors that precipitate hepatic encephalopathy cause increases in ammonia levels, and (c) treatments that relieve hepatic encephalopathy lower ammonia levels