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YC edited the manuscript and supervised the work
Clinically isolated syndrome (CIS) A first attack of neurological disability with accompanying white matter lesion(s) on imaging, that may or may not develop into MS characterized by recurrent lesions distributed in space and time
In addition, fasting-induced improvements in insulin sensitivity and reductions in systemic inflammation may indirectly support gonadal steroidogenesis by restoring optimal Leydig cell responsiveness, which is crucial for testosterone production [58]
PMID 3107223
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