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A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

Folic acid when taken in a larger dose for a prolonged duration can impair the therapeutic response of Mecobalamin

It is produced either in a de novo pathway from amino acids or in salvage pathways by recycling preformed components such as nicotinamide back to NAD +

10.1016/j.ebiom.2018.01.012 EBioMedicine 37 JinY.LuS

Post-treatment care is important for maximizing benefits