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Slowed gastric emptying increases the risk of acid reflux

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While semaglutide reduces appetite in most users, weight gain occurs when calorie intake exceeds expenditure despite medication, often from tolerance development, compensatory overeating during symptom plateaus, or increased insulin sensitivity driving food calories into fat storage

Pancreatic and gallbladder concerns have been reported with GLP-1 agonists, though causal links remain under investigation

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