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Once reconstituted, it becomes susceptible to hydrolysis, oxidation, and microbial contamination making correct handling and storage critically important for patient safety

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however, differences in injection frequency, dose escalation, and device design meant that investigators were not blinded to which active treatment participants received [1]

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56 Our findings build on two previously reported PDAC-specific characteristics, namely, 1st RAS signaling driving glutamine metabolism for ROS homeostasis 22,50,51 and 2nd mitochondrial dependency upon genetic loss of the KRAS oncogene, 41 and connect them with a more generally described cancer cell state associated with therapy resistance, characterized by a dependence on lipid peroxidation defense pathways